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aspc1  (ATCC)
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ATCC aspc1
Aspc1, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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aspc1 crl 1682  (ATCC)
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aspc1 pancreatic ductal adenocarcinoma cells  (ATCC)
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ATCC aspc1 pancreatic ductal adenocarcinoma cells
Collagen-rich environments restrict CAR T cell migration, limiting cytotoxicity (A) Trajectories of CAR T cells embedded in 2 mg/mL (low) and 4 mg/mL (high) collagen gels. Scale bars, 50 μm. (B and C) Speed and displacement of CAR T cells seeded at low and high collagen densities. N = 3, n = 50 cells, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001. (D) Cartoon depicting an assembloid with PDAC cells in the core surrounded by a stromal compartment composed of a low or high density of collagen. CAR T cells seeded in medium on top of the bulk matrix can more readily invade compartments composed of a low collagen density compared to a high collagen density. (E). <t>ASPC1</t> cells (gold) and CAR T cells (green) in medium coculture of varying collagen densities. Images are maximum intensity projections of stacks of fluorescence confocal images. 10X magnification. Scale bars, 250 μm. (F) Cytotoxicity of CAR T cells against PDAC 3D in varying collagen densities of the medium coculture. E:T ratio, 1. N = 3, n = 3+, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001.
Aspc1 Pancreatic Ductal Adenocarcinoma Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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crl 1469 aspc1 atcc  (ATCC)
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ATCC crl 1469 aspc1 atcc
Collagen-rich environments restrict CAR T cell migration, limiting cytotoxicity (A) Trajectories of CAR T cells embedded in 2 mg/mL (low) and 4 mg/mL (high) collagen gels. Scale bars, 50 μm. (B and C) Speed and displacement of CAR T cells seeded at low and high collagen densities. N = 3, n = 50 cells, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001. (D) Cartoon depicting an assembloid with PDAC cells in the core surrounded by a stromal compartment composed of a low or high density of collagen. CAR T cells seeded in medium on top of the bulk matrix can more readily invade compartments composed of a low collagen density compared to a high collagen density. (E). <t>ASPC1</t> cells (gold) and CAR T cells (green) in medium coculture of varying collagen densities. Images are maximum intensity projections of stacks of fluorescence confocal images. 10X magnification. Scale bars, 250 μm. (F) Cytotoxicity of CAR T cells against PDAC 3D in varying collagen densities of the medium coculture. E:T ratio, 1. N = 3, n = 3+, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001.
Crl 1469 Aspc1 Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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500k aspc1 cells  (ATCC)
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ATCC 500k aspc1 cells
Collagen-rich environments restrict CAR T cell migration, limiting cytotoxicity (A) Trajectories of CAR T cells embedded in 2 mg/mL (low) and 4 mg/mL (high) collagen gels. Scale bars, 50 μm. (B and C) Speed and displacement of CAR T cells seeded at low and high collagen densities. N = 3, n = 50 cells, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001. (D) Cartoon depicting an assembloid with PDAC cells in the core surrounded by a stromal compartment composed of a low or high density of collagen. CAR T cells seeded in medium on top of the bulk matrix can more readily invade compartments composed of a low collagen density compared to a high collagen density. (E). <t>ASPC1</t> cells (gold) and CAR T cells (green) in medium coculture of varying collagen densities. Images are maximum intensity projections of stacks of fluorescence confocal images. 10X magnification. Scale bars, 250 μm. (F) Cytotoxicity of CAR T cells against PDAC 3D in varying collagen densities of the medium coculture. E:T ratio, 1. N = 3, n = 3+, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001.
500k Aspc1 Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human 141 aspc1  (ATCC)
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ATCC human 141 aspc1
Collagen-rich environments restrict CAR T cell migration, limiting cytotoxicity (A) Trajectories of CAR T cells embedded in 2 mg/mL (low) and 4 mg/mL (high) collagen gels. Scale bars, 50 μm. (B and C) Speed and displacement of CAR T cells seeded at low and high collagen densities. N = 3, n = 50 cells, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001. (D) Cartoon depicting an assembloid with PDAC cells in the core surrounded by a stromal compartment composed of a low or high density of collagen. CAR T cells seeded in medium on top of the bulk matrix can more readily invade compartments composed of a low collagen density compared to a high collagen density. (E). <t>ASPC1</t> cells (gold) and CAR T cells (green) in medium coculture of varying collagen densities. Images are maximum intensity projections of stacks of fluorescence confocal images. 10X magnification. Scale bars, 250 μm. (F) Cytotoxicity of CAR T cells against PDAC 3D in varying collagen densities of the medium coculture. E:T ratio, 1. N = 3, n = 3+, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001.
Human 141 Aspc1, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human aspc1  (ATCC)
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ATCC human aspc1
BRCA2 mutated pancreatic cancer is sensitive to platinum-based chemotherapy. (A) MTT assay of KPC, KPCB.c1 or KPCB.c2 at varying doses of cisplatin ( n = 3 per group). (B) MTT assay of <t>ASPC1</t> (human PDAC non-BRCA mutated) and CAPAN1 (human PDAC BRCA2 mutated) cell lines at varying doses of cisplatin ( n = 3 per group). (C) Experimental design for D-E ( n = 5 per group). (D) Tumor growth curves. Numbers represent survival at end of experiment. (E) Kaplan-Meier plot. (F) Experimental design for G-H ( n = 5 per group). (G) Tumor growth curves. Numbers represent survival at end of experiment. (H) Kaplan-Meier plot. Two way ANOVA was used to compare MTT assays between KPC and KPCB.c1 or KPCB.c2 treated with cisplatin. For the rest of the data, one way ANOVA with Tukey correction for multiple comparisons and Log-rank test were used to determine statistical significance. Statistical significance denoted as n.s. p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001 and ****, p < 0.0001.
Human Aspc1, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Collagen-rich environments restrict CAR T cell migration, limiting cytotoxicity (A) Trajectories of CAR T cells embedded in 2 mg/mL (low) and 4 mg/mL (high) collagen gels. Scale bars, 50 μm. (B and C) Speed and displacement of CAR T cells seeded at low and high collagen densities. N = 3, n = 50 cells, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001. (D) Cartoon depicting an assembloid with PDAC cells in the core surrounded by a stromal compartment composed of a low or high density of collagen. CAR T cells seeded in medium on top of the bulk matrix can more readily invade compartments composed of a low collagen density compared to a high collagen density. (E). ASPC1 cells (gold) and CAR T cells (green) in medium coculture of varying collagen densities. Images are maximum intensity projections of stacks of fluorescence confocal images. 10X magnification. Scale bars, 250 μm. (F) Cytotoxicity of CAR T cells against PDAC 3D in varying collagen densities of the medium coculture. E:T ratio, 1. N = 3, n = 3+, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001.

Journal: Cell Reports Methods

Article Title: A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity

doi: 10.1016/j.crmeth.2026.101307

Figure Lengend Snippet: Collagen-rich environments restrict CAR T cell migration, limiting cytotoxicity (A) Trajectories of CAR T cells embedded in 2 mg/mL (low) and 4 mg/mL (high) collagen gels. Scale bars, 50 μm. (B and C) Speed and displacement of CAR T cells seeded at low and high collagen densities. N = 3, n = 50 cells, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001. (D) Cartoon depicting an assembloid with PDAC cells in the core surrounded by a stromal compartment composed of a low or high density of collagen. CAR T cells seeded in medium on top of the bulk matrix can more readily invade compartments composed of a low collagen density compared to a high collagen density. (E). ASPC1 cells (gold) and CAR T cells (green) in medium coculture of varying collagen densities. Images are maximum intensity projections of stacks of fluorescence confocal images. 10X magnification. Scale bars, 250 μm. (F) Cytotoxicity of CAR T cells against PDAC 3D in varying collagen densities of the medium coculture. E:T ratio, 1. N = 3, n = 3+, donors = 2. Data are mean ± SEM. Statistical test: unpaired t test, ∗∗∗∗ p < 0.0001.

Article Snippet: OVCAR3 ovarian cancer cells (ATCC HTB-161), MDA-MB-231 breast cancer cells (ATCC HTB-26), JAR gestational trophoblastic neoplasia cells (ATCC HTB-144), 293T (ATCC CRL-3216) as well as PANC-1 and ASPC1 pancreatic ductal adenocarcinoma cells (ATCC CRL-1469) were cultured according to ATCC recommendations.

Techniques: Migration, Fluorescence

BRCA2 mutated pancreatic cancer is sensitive to platinum-based chemotherapy. (A) MTT assay of KPC, KPCB.c1 or KPCB.c2 at varying doses of cisplatin ( n = 3 per group). (B) MTT assay of ASPC1 (human PDAC non-BRCA mutated) and CAPAN1 (human PDAC BRCA2 mutated) cell lines at varying doses of cisplatin ( n = 3 per group). (C) Experimental design for D-E ( n = 5 per group). (D) Tumor growth curves. Numbers represent survival at end of experiment. (E) Kaplan-Meier plot. (F) Experimental design for G-H ( n = 5 per group). (G) Tumor growth curves. Numbers represent survival at end of experiment. (H) Kaplan-Meier plot. Two way ANOVA was used to compare MTT assays between KPC and KPCB.c1 or KPCB.c2 treated with cisplatin. For the rest of the data, one way ANOVA with Tukey correction for multiple comparisons and Log-rank test were used to determine statistical significance. Statistical significance denoted as n.s. p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001 and ****, p < 0.0001.

Journal: Scientific Reports

Article Title: Sequential platinum and PARP Inhibition enhances PD1 immunotherapy efficacy in murine Brca2 mutated pancreatic cancer

doi: 10.1038/s41598-026-35423-7

Figure Lengend Snippet: BRCA2 mutated pancreatic cancer is sensitive to platinum-based chemotherapy. (A) MTT assay of KPC, KPCB.c1 or KPCB.c2 at varying doses of cisplatin ( n = 3 per group). (B) MTT assay of ASPC1 (human PDAC non-BRCA mutated) and CAPAN1 (human PDAC BRCA2 mutated) cell lines at varying doses of cisplatin ( n = 3 per group). (C) Experimental design for D-E ( n = 5 per group). (D) Tumor growth curves. Numbers represent survival at end of experiment. (E) Kaplan-Meier plot. (F) Experimental design for G-H ( n = 5 per group). (G) Tumor growth curves. Numbers represent survival at end of experiment. (H) Kaplan-Meier plot. Two way ANOVA was used to compare MTT assays between KPC and KPCB.c1 or KPCB.c2 treated with cisplatin. For the rest of the data, one way ANOVA with Tukey correction for multiple comparisons and Log-rank test were used to determine statistical significance. Statistical significance denoted as n.s. p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001 and ****, p < 0.0001.

Article Snippet: Human ASPC1 and CAPAN1 cells were obtained from ATCC.

Techniques: MTT Assay